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Research progress on the effects and mechanisms of Cavin family on diabetic insulin resistence

• 1、Endocrinology Department, The First Affiliated Hospital of Sun Yat-sen University,

Abstract：Type 2 diabetes is a metabolic disease characterized by multiple causes of chronic hyperglycemia, which is characterized mainly by insulin resistance with insulin progressive hyposecretion to mainly by insulin hyposecretion with insulin resistence. During the initiation and development of diabetes and its complications, insulin resistance is an important pathological mechanism in the pathological process of glucose metabolism, lipid, protein metabolism disorder, insulin resistance, large blood vessel and microvascular progressive damage. Caveolae is located on many cell surfaces of vertebrates, mediating insulin receptor and participating in signal transduction related to fat, glucose transport and insulin resistance. In order to provide new ideas for the insulin resistance, the role and possible mechanism of Cavin family proteins on the regulation for structure, number and function throuhg the role of insulin receptor and post receptor signaling pathway in insulin resistance are studied.

Keywords： insulin resistence caveolae；insulin receptor；lipid droplet